The Pleiades Promoter Project

All MiniPromoters

Ple47-lacZ (Negative)

Other constructs for this MiniPromoter: Ple47-EGFP (Negative)

Other constructs for this Gene: Ple44-EGFP (Negative), Ple45-EGFP (Negative), Ple46-EGFP (Negative)

The images are coming soon!

The description is coming soon!

Note: Promoterless negative controls (pEMS1302, pEMS1306, pEMS1313) have been generated, as well as CAG positive controls (pEMS1157, pEMS1277 & pEMS1488).

Ple47-lacZ
	plasmid pEMS1518 (in backbone pEMS1313)
	ESCs mEMS4073, mEMS4097, mEMS4099, mEMS4106
	mice generated using ESC mEMS4073
Resource Files
	Ple47 pEMS1518 Vector NTI File (Requires VectorNTI Sofware)	Holt lab
	Ple47 pEMS1518 Vector Map	Holt lab
	Ple47 pEMS1518 Genotyping Assay (Requires VectorNTI Sofware)	Holt lab

Reference	PubMed ID
Garin A, Pellet P, Deterre P, Debre P, Combadiere C. Cloning and functional characterization of the human fractalkine receptor promoter regions. Biochem J. 2002 Dec 15;368(Pt 3):753-60.	12234253
Chen S, Luo D, Streit WJ, Harrison JK. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. J Neuroimmunol. 2002 Dec;133(1-2):46-55.	12446007
DeVries ME, Cao H, Wang J, Xu L, Kelvin AA, Ran L, Chau LA, Madrenas J, Hegele RA, Kelvin DJ. Genomic organization and evolution of the CX3CR1/CCR8 chemokine receptor locus. J Biol Chem. 2003 Apr 4;278(14):11985-94. Epub 2003 Jan 27.	12551893
Barlic J, McDermott DH, Merrell MN, Gonzales J, Via LE, Murphy PM. Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms. J Biol Chem. 2004 Nov 19;279(47):48520-34. Epub 2004 Sep 3.	15347678
Yang X, Hu J, Zhang J, Guan H. Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. Br J Ophthalmol. 2010 Jun 10; [Epub ahead of print]	20538655
Tserel L, Kolde R, Rebane A, Kisand K, Org T, Peterson H, Vilo J, Peterson P. Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics. 2010 Nov 18;11(1):642 [Epub ahead of print]	21087476